HTCC: Broad Range Inhibitor of Coronavirus Entry
Identifieur interne : 001227 ( Main/Exploration ); précédent : 001226; suivant : 001228HTCC: Broad Range Inhibitor of Coronavirus Entry
Auteurs : Aleksandra Milewska [Pologne] ; Kamil Kaminski [Pologne] ; Justyna Ciejka [Pologne] ; Katarzyna Kosowicz [Pologne] ; Slawomir Zeglen [Pologne] ; Jacek Wojarski [Pologne] ; Maria Nowakowska [Pologne] ; Krzysztof Szczubiałka [Pologne] ; Krzysztof Pyrc [Pologne]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- analogues et dérivés : Chitosane.
- pharmacologie : Antiviraux, Chitosane, Composés d'ammonium quaternaire.
- physiologie : Coronavirus.
- Animaux, Coronavirus, Fusion membranaire, Humains, Lignée cellulaire, Macaca mulatta, Réplication virale.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (pharmacology), Cell Line, Chitosan (analogs & derivatives), Chitosan (pharmacology), Coronavirus (drug effects), Coronavirus (physiology), Humans, Macaca mulatta, Membrane Fusion (drug effects), Quaternary Ammonium Compounds (pharmacology), Virus Replication (drug effects).
- MESH :
- chemical , analogs & derivatives : Chitosan.
- chemical , pharmacology : Antiviral Agents, Chitosan, Quaternary Ammonium Compounds.
- drug effects : Coronavirus, Membrane Fusion, Virus Replication.
- physiology : Coronavirus.
- Animals, Cell Line, Humans, Macaca mulatta.
Abstract
To date, six human coronaviruses have been known, all of which are associated with respiratory infections in humans. With the exception of the highly pathogenic SARS and MERS coronaviruses, human coronaviruses (HCoV-NL63, HCoV-OC43, HCoV-229E, and HCoV-HKU1) circulate worldwide and typically cause the common cold. In most cases, infection with these viruses does not lead to severe disease, although acute infections in infants, the elderly, and immunocompromised patients may progress to severe disease requiring hospitalization. Importantly, no drugs against human coronaviruses exist, and only supportive therapy is available. Previously, we proposed the cationically modified chitosan, N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC), and its hydrophobically-modified derivative (HM-HTCC) as potent inhibitors of the coronavirus HCoV-NL63. Here, we show that HTCC inhibits interaction of a virus with its receptor and thus blocks the entry. Further, we demonstrate that HTCC polymers with different degrees of substitution act as effective inhibitors of all low-pathogenic human coronaviruses.
Url:
DOI: 10.1371/journal.pone.0156552
PubMed: 27249425
PubMed Central: 4889042
Affiliations:
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Zabrze</wicri:noRegion></affiliation></author><author><name sortKey="Wojarski, Jacek" sort="Wojarski, Jacek" uniqKey="Wojarski J" first="Jacek" last="Wojarski">Jacek Wojarski</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Department of Cardiac Surgery and Transplantology, Silesian Center for Heart Diseases, Marii Curie-Skłodowskiej 9, 41-800 Zabrze, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Cardiac Surgery and Transplantology, Silesian Center for Heart Diseases, Marii Curie-Skłodowskiej 9, 41-800 Zabrze</wicri:regionArea><wicri:noRegion>41-800 Zabrze</wicri:noRegion></affiliation></author><author><name sortKey="Nowakowska, Maria" sort="Nowakowska, Maria" uniqKey="Nowakowska M" first="Maria" last="Nowakowska">Maria Nowakowska</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland</addr-line></nlm:aff><country 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xml:lang="fr">Pologne</country><wicri:regionArea>Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow</wicri:regionArea><wicri:noRegion>30-387 Krakow</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30–387 Krakow, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30–387 Krakow</wicri:regionArea><wicri:noRegion>30–387 Krakow</wicri:noRegion></affiliation></author><author><name sortKey="Kaminski, Kamil" sort="Kaminski, Kamil" uniqKey="Kaminski K" first="Kamil" last="Kaminski">Kamil Kaminski</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow</wicri:regionArea><wicri:noRegion>30-060 Krakow</wicri:noRegion></affiliation></author><author><name sortKey="Ciejka, Justyna" sort="Ciejka, Justyna" uniqKey="Ciejka J" first="Justyna" last="Ciejka">Justyna Ciejka</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30–387 Krakow, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30–387 Krakow</wicri:regionArea><wicri:noRegion>30–387 Krakow</wicri:noRegion></affiliation></author><author><name sortKey="Kosowicz, Katarzyna" sort="Kosowicz, Katarzyna" uniqKey="Kosowicz K" first="Katarzyna" last="Kosowicz">Katarzyna Kosowicz</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow</wicri:regionArea><wicri:noRegion>30-387 Krakow</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30–387 Krakow, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30–387 Krakow</wicri:regionArea><wicri:noRegion>30–387 Krakow</wicri:noRegion></affiliation></author><author><name sortKey="Zeglen, Slawomir" sort="Zeglen, Slawomir" uniqKey="Zeglen S" first="Slawomir" last="Zeglen">Slawomir Zeglen</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Department of Cardiac Surgery and Transplantology, Silesian Center for Heart Diseases, Marii Curie-Skłodowskiej 9, 41-800 Zabrze, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Cardiac Surgery and Transplantology, Silesian Center for Heart Diseases, Marii Curie-Skłodowskiej 9, 41-800 Zabrze</wicri:regionArea><wicri:noRegion>41-800 Zabrze</wicri:noRegion></affiliation></author><author><name sortKey="Wojarski, Jacek" sort="Wojarski, Jacek" uniqKey="Wojarski J" first="Jacek" last="Wojarski">Jacek Wojarski</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Department of Cardiac Surgery and Transplantology, Silesian Center for Heart Diseases, Marii Curie-Skłodowskiej 9, 41-800 Zabrze, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Cardiac Surgery and Transplantology, Silesian Center for Heart Diseases, Marii Curie-Skłodowskiej 9, 41-800 Zabrze</wicri:regionArea><wicri:noRegion>41-800 Zabrze</wicri:noRegion></affiliation></author><author><name sortKey="Nowakowska, Maria" sort="Nowakowska, Maria" uniqKey="Nowakowska M" first="Maria" last="Nowakowska">Maria Nowakowska</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow</wicri:regionArea><wicri:noRegion>30-060 Krakow</wicri:noRegion></affiliation></author><author><name sortKey="Szczubialka, Krzysztof" sort="Szczubialka, Krzysztof" uniqKey="Szczubialka K" first="Krzysztof" last="Szczubiałka">Krzysztof Szczubiałka</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow</wicri:regionArea><wicri:noRegion>30-060 Krakow</wicri:noRegion></affiliation></author><author><name sortKey="Pyrc, Krzysztof" sort="Pyrc, Krzysztof" uniqKey="Pyrc K" first="Krzysztof" last="Pyrc">Krzysztof Pyrc</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow</wicri:regionArea><wicri:noRegion>30-387 Krakow</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30–387 Krakow, Poland</addr-line></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30–387 Krakow</wicri:regionArea><wicri:noRegion>30–387 Krakow</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Cell Line</term><term>Chitosan (analogs & derivatives)</term><term>Chitosan (pharmacology)</term><term>Coronavirus (drug effects)</term><term>Coronavirus (physiology)</term><term>Humans</term><term>Macaca mulatta</term><term>Membrane Fusion (drug effects)</term><term>Quaternary Ammonium Compounds (pharmacology)</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux (pharmacologie)</term><term>Chitosane (analogues et dérivés)</term><term>Chitosane (pharmacologie)</term><term>Composés d'ammonium quaternaire (pharmacologie)</term><term>Coronavirus ()</term><term>Coronavirus (physiologie)</term><term>Fusion membranaire ()</term><term>Humains</term><term>Lignée cellulaire</term><term>Macaca mulatta</term><term>Réplication virale ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Chitosan</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Chitosan</term><term>Quaternary Ammonium Compounds</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Chitosane</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Coronavirus</term><term>Membrane Fusion</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Chitosane</term><term>Composés d'ammonium quaternaire</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Humans</term><term>Macaca mulatta</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Coronavirus</term><term>Fusion membranaire</term><term>Humains</term><term>Lignée cellulaire</term><term>Macaca mulatta</term><term>Réplication virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>To date, six human coronaviruses have been known, all of which are associated with respiratory infections in humans. With the exception of the highly pathogenic SARS and MERS coronaviruses, human coronaviruses (HCoV-NL63, HCoV-OC43, HCoV-229E, and HCoV-HKU1) circulate worldwide and typically cause the common cold. In most cases, infection with these viruses does not lead to severe disease, although acute infections in infants, the elderly, and immunocompromised patients may progress to severe disease requiring hospitalization. Importantly, no drugs against human coronaviruses exist, and only supportive therapy is available. Previously, we proposed the cationically modified chitosan, N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC), and its hydrophobically-modified derivative (HM-HTCC) as potent inhibitors of the coronavirus HCoV-NL63. Here, we show that HTCC inhibits interaction of a virus with its receptor and thus blocks the entry. Further, we demonstrate that HTCC polymers with different degrees of substitution act as effective inhibitors of all low-pathogenic human coronaviruses.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fields, Bn" uniqKey="Fields B">BN Fields</name></author><author><name sortKey="Knipe, Dm" uniqKey="Knipe D">DM Knipe</name></author><author><name sortKey="Howley, Pm" uniqKey="Howley P">PM Howley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Stohr, K" uniqKey="Stohr K">K Stöhr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stadler, K" uniqKey="Stadler K">K Stadler</name></author><author><name sortKey="Masignani, V" uniqKey="Masignani V">V Masignani</name></author><author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M Eickmann</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S Becker</name></author><author><name sortKey="Abrignani, S" uniqKey="Abrignani S">S Abrignani</name></author><author><name sortKey="Klenk, Hd" uniqKey="Klenk H">HD Klenk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name></author><author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Brown, Cs" uniqKey="Brown C">CS Brown</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L Enjuanes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM 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Zhang</name></author><author><name sortKey="Hao, C" uniqKey="Hao C">C Hao</name></author><author><name sortKey="Zhang, Xe" uniqKey="Zhang X">XE Zhang</name></author><author><name sortKey="Cui, Zq" uniqKey="Cui Z">ZQ Cui</name></author><author><name sortKey="Guan, Hs" uniqKey="Guan H">HS Guan</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Pologne</li></country></list><tree><country name="Pologne"><noRegion><name sortKey="Milewska, Aleksandra" sort="Milewska, Aleksandra" uniqKey="Milewska A" first="Aleksandra" last="Milewska">Aleksandra Milewska</name></noRegion><name sortKey="Ciejka, Justyna" sort="Ciejka, Justyna" uniqKey="Ciejka J" first="Justyna" last="Ciejka">Justyna Ciejka</name><name sortKey="Kaminski, Kamil" sort="Kaminski, Kamil" uniqKey="Kaminski K" first="Kamil" last="Kaminski">Kamil Kaminski</name><name sortKey="Kosowicz, Katarzyna" sort="Kosowicz, Katarzyna" uniqKey="Kosowicz K" first="Katarzyna" last="Kosowicz">Katarzyna Kosowicz</name><name sortKey="Kosowicz, Katarzyna" sort="Kosowicz, Katarzyna" uniqKey="Kosowicz K" first="Katarzyna" last="Kosowicz">Katarzyna Kosowicz</name><name sortKey="Milewska, Aleksandra" sort="Milewska, Aleksandra" uniqKey="Milewska A" first="Aleksandra" last="Milewska">Aleksandra Milewska</name><name sortKey="Nowakowska, Maria" sort="Nowakowska, Maria" uniqKey="Nowakowska M" first="Maria" last="Nowakowska">Maria Nowakowska</name><name sortKey="Pyrc, Krzysztof" sort="Pyrc, Krzysztof" uniqKey="Pyrc K" first="Krzysztof" last="Pyrc">Krzysztof Pyrc</name><name sortKey="Pyrc, Krzysztof" sort="Pyrc, Krzysztof" uniqKey="Pyrc K" first="Krzysztof" last="Pyrc">Krzysztof Pyrc</name><name sortKey="Szczubialka, Krzysztof" sort="Szczubialka, Krzysztof" uniqKey="Szczubialka K" first="Krzysztof" last="Szczubiałka">Krzysztof Szczubiałka</name><name sortKey="Wojarski, Jacek" sort="Wojarski, Jacek" uniqKey="Wojarski J" first="Jacek" last="Wojarski">Jacek Wojarski</name><name sortKey="Zeglen, Slawomir" sort="Zeglen, Slawomir" uniqKey="Zeglen S" first="Slawomir" last="Zeglen">Slawomir Zeglen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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